The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications
The insulin receptor (IR) presents by alternative splicing two isoforms: IRA and IRB.The differential physiological and pathological role of both isoforms is not completely known, and it is determinant the different binding affinity for insulin-like growth factor.IRB is more abundant in adult tissues and it nailah american idol exerts mainly the me